Nitrazepam has been related to serious hepatic Issues, similar to other nitrobenzodiazepines. Nitrobenzodiazepines including nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more toxic for the liver than other benzodiazepines as They are really metabolically activated by CYP3A4 which may result in cytotoxicity.[thirty] Warning must